Great moments in mid-major conferences

2005: Twelve-seed UW-Milwaukee defeats four-seed Boston College in the second round.
2005: Fourteen-seed Bucknell beats three-seed Kansas.
2004: Twelve-seed Pacific beats four-seed Providence.
2004: Twelve-seed Manhattan beats four-seed Florida.
2003: Thirteen-seed Tulsa beats four-seed Dayton.
2003: Twelve-seed Butler beats four-seed Louisville in the second round.
2001: Fifteen-seed Hampton beats two-seed Iowa State.
2001: Thirteen-seed Indiana State beats four-seed Oklahoma.
1999: Fourteen-seed Weber State beats three-seed North Carolina.
1997: Fifteen-seed Coppin State beats two-seed South Carolina.
1996: Thirteen-seed Princeston beats four-seed UCLA.
1995: Fourteen-seed Old Dominion beats three-seed Villanova in three overtimes.
1993: Fifteen-seed Santa Clara beats two-seed Arizona.
1993: Thirteen-seed Southern beats four-seed Georgia Tech.
1991: Fifteen-seed Richmond beats two-seed Syracuse.
1990: Fourteen-seed Northern Iowa beats three-seed Missouri.
1988: Thirteen-seed Richmond beats four-seed Indiana.
1988: Fourteen-seed Murray State beats three-seed N.C. State.
1986: Fourteen-seed Cleveland State beats three-seed Indiana.
1986: Fourteen-seed Arkansas State beats three-seed Notre Dame.

And while no sixteen-seed has ever beaten a one-seed, here are some close calls:

1996: Purdue 73, Western Carolina 71
1990: Michigan State 75, Murray State 71 (OT)
1989: Georgetown 50, Princeton 49
1989: Oklahoma 72, East Tennessee State 71